San Diego Zoo Hours Of Operation 2025. First we would recommend making time for the 35 minute guided bus tour and the skyfari. Weekdays, especially tuesday through thursday, are quieter and provide a more relaxed experience.
The san diego zoo typically opens at 9:00 am and closes at 5:00 pm, but hours may vary depending on the time of year. For a quieter, more enjoyable experience, consider visiting on weekdays.